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中文名称：小鼠抗ANKRD53单克隆抗体
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Background: |
Ankyrins are membrane adaptor molecules that play important roles in coupling integral membrane proteins to the spectrin-based cytoskeleton network. Mutations of ankyrin genes lead to severe genetic diseases, such as fatal cardiac arrhythmias and hereditary spherocytosis. ANKRD53 (ankyrin repeat domain 53) is a 530 amino acid protein that contains three ANK repeats. Conserved in chimpanzee, dog, cow, mouse and zebrafish, ANKRD53 is encoded by a gene that maps to human chromosome 2p13.3. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. Chromosome 2 contains a probable vestigial second centromere, as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes. |
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Applications: |
WB, IF, FC |
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Name of antibody: |
ANKRD53 |
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Immunogen: |
Fusion protein of human ANKRD53 |
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Full name: |
ankyrin repeat domain 53 (ANKRD53), transcript variant 2 |
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Synonyms: |
FLJ12056; FLJ36160 |
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SwissProt: |
Q8N9V6 |
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WB Predicted band size: |
60 kDa |
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WB Positive control: |
HepG2, Hela, SVT2 cell lysates |
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WB Recommended dilution: |
200-1000 |
