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Background: |
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
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Applications: |
WB |
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Name of antibody: |
SMAD2(Ab-465) |
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Immunogen: |
Synthesized peptide derived from C-terminal of human Smad2. |
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Full name: |
SMAD family member 2 |
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Synonyms： |
JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2 |
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SwissProt: |
Q15796 |
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WB Predicted band size: |
52 kDa |
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WB Positive control: |
293 cells, JurKat cells, HepG2 cells and K562 cells lysates |
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WB Recommended dilution: |
500-3000 |
