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标 记 物: Unconjugate
技术规格
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Background: |
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
HLA-DPA1 |
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Immunogen: |
Synthetic peptide of human HLA-DPA1 |
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Full name: |
major histocompatibility complex, class II, DP alpha 1 |
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Synonyms: |
PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A |
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SwissProt: |
P20036 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human tonsil |
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IHC Recommend dilution: |
40-200 |
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WB Predicted band size: |
29 kDa |
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WB Positive control: |
Raji cell, Human spleen tissue lysates |
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WB Recommended dilution: |
500-2000 |
