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    ÖÐÎÄÃû³Æ£º  Íÿ¹PTPN2¶à¿Ë¡¿¹Ìå


    Ó¢ÎÄÃû³Æ£º  Anti-PTPN2 rabbit polyclonal antibody


    ±ð       Ãû£º PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP


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    ´¢       ´æ£º Àä¶³£¨-20¡æ£© ±Ü¹â


    ËÞ       Ö÷£º Rabbit


    ¿¹      Ô­£º PTPN2


    ·´Ó¦ÖÖÊô£º Human, Mouse, Rat


    ±ê  ¼Ç  Î Unconjugate


    ¿Ë¡ÀàÐÍ£º rabbit polyclonal


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    Background:

    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.

    Applications:

    WB

    Name of antibody:

    PTPN2

    Immunogen:

    Fusion protein of human PTPN2

    Full name:

    protein tyrosine phosphatase, non-receptor type 2

    Synonyms£º

    PTN2; PTPT; TCPTP; TC-PTP; TCELLPTP

    SwissProt:

    P17706

    WB Predicted band size:

    49 kDa

    WB Positive control:

    SW680, BT474, Jurkat and K562 cells

    WB Recommended dilution:

    500-2000




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