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021-54845833/15800441009
中文名称：小鼠抗FADD单克隆抗体
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Background: |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. |
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Applications: |
WB, IP |
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Name of antibody: |
FADD |
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Immunogen: |
Fusion protein of human FADD |
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Full name: |
Fas associated via death domain |
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Synonyms: |
GIG3; MORT1 |
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SwissProt: |
Q13158 |
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WB Predicted band size: |
23 kDa |
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WB Positive control: |
SW480, Jurkat and Hela cell lysates |
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WB Recommended dilution: |
500-2000 |
