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021-54845833/15800441009
中文名称 : 小鼠抗F13A1单克隆抗体
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Background: |
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]. |
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Applications: |
WB, IHC |
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Name of antibody: |
F13A1 |
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Immunogen: |
Fusion protein of human F13A1 |
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Full name: |
coagulation factor XIII, A1 polypeptide (F13A1) |
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Synonyms: |
F13A |
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SwissProt: |
P00488 |
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IHC positive control: |
carcinoma of human bladder tissue and human lymph node tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
83 kDa |
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WB Positive control: |
A549 cell lysate |
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WB Recommended dilution: |
500-2000 |
