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中文名称：SETD2抗原（重组蛋白）
英文名称： SETD2 Antigen (Recombinant Protein)
别 名： HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to C terminal 250 amino acids of human SETD2 |
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Full name: |
SET domain containing 2 |
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Synonyms: |
HYPB; SET2; HIF-1; HIP-1; KMT3A; HBP231; HSPC069; p231HBP |
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Swissprot: |
Q9BYW2 |
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Gene Accession: |
BC117162 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II. |
