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中文名称：IFT57抗原（重组蛋白）
英文名称： IFT57 Antigen (Recombinant Protein)
别 名： HIPPI; MHS4R2; ESRRBL1
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 230-429 amino acids of human IFT57 |
|
Full name: |
intraflagellar transport 57 |
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Synonyms: |
HIPPI; MHS4R2; ESRRBL1 |
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Swissprot: |
Q9NWB7 |
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Gene Accession: |
BC011899 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. |
