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021-54845833/15800441009
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Background: |
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
JAK1 |
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Immunogen: |
Synthetic peptide of human JAK1 |
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Full name: |
Janus kinase 1 |
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Synonyms: |
JTK3; JAK1A; JAK1B |
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SwissProt: |
P23458 |
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ELISA Recommended dilution: |
500-1000 |
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IHC positive control: |
Human tonsil |
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IHC Recommend dilution: |
25-100 |
