购物车
帮助
021-54845833/15800441009
中文名称： 小鼠抗PSMC3单克隆抗体
|
Background: |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. |
|
Applications: |
WB |
|
Name of antibody: |
PSMC3 |
|
Immunogen: |
Fusion protein of human PSMC3 |
|
Full name: |
proteasome 26S subunit, ATPase 3 |
|
Synonyms: |
TBP1 |
|
SwissProt: |
P17980 |
|
WB Predicted band size: |
49 KD |
|
WB Positive control: |
293T, Hela, HepG2, A431 cell lysates |
|
WB Recommended dilution: |
200-1000 |
