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021-54845833/15800441009
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Background: |
Catenin alpha-1 is a protein that in humans is encoded by the CTNNA1 gene. Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
CTNNA1 |
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Immunogen: |
Fusion protein of human CTNNA1 |
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Full name: |
Catenin (cadherin-associated protein), alpha 1, 102kDa |
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Synonyms: |
CAP102 |
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SwissProt: |
P35221 |
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IHC positive control: |
Human gastric cancer |
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IHC Recommend dilution: |
50-200 |
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WB Predicted band size: |
100 kDa |
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WB Positive control: |
A431 cells |
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WB Recommended dilution: |
500-2000 |
