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中文名称：APEX1抗原（重组蛋白）
英文名称：APEX1 Antigen (Recombinant Protein)
储 存：冷冻（-20℃）
相关类别：抗原
概述
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Fusion protein corresponding to a region derived from 15-224 amino acids of human APEX1 |
技术规格
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Full name: |
APEX nuclease (multifunctional DNA repair enzyme) 1 |
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Synonyms: |
APE; APX; APE1; APEN; APEX; HAP1; REF1 |
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Swissprot: |
P27695 |
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Gene Accession: |
BC004979 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein. |
