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021-54845833/15800441009
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Fusion protein corresponding to a region derived from 530-847 amino acids of human STAT6 |
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Full name: |
signal transducer and activator of transcription 6, interleukin-4 induced |
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Synonyms: |
STAT6B; STAT6C; D12S1644; IL-4-STAT |
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Swissprot: |
P42226 |
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Gene Accession: |
BC075852 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. Alternative splicing results in multiple transcript variants. |
