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中文名称： MAP3K7 抗原（重组蛋白）
英文名称： MAP3K7 Antigen (Recombinant Protein)
别 名： mitogen-activated protein kinase kinase kinase 7; CSCF; FMD2; TAK1; MEKK7; TGF1a
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述
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Fusion protein corresponding to a region derived from 401-579 amino acids of human MAP3K7 |
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Full name: |
mitogen-activated protein kinase kinase kinase 7 |
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Synonyms: |
CSCF; FMD2; TAK1; MEKK7; TGF1a |
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Swissprot: |
O43318 |
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Gene Accession: |
BC017715 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. |
