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Background: |
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE production. The encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Polymorphisms in this gene are also associated with resistance to human immunodeficiency virus type-1 infection. Alternate splicing results in multiple transcript variants. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
IL4R |
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Immunogen: |
Synthetic peptide of human IL4R |
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Full name: |
interleukin 4 receptor |
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Synonyms: |
CD124; IL4RA; IL-4RA |
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SwissProt: |
P24394 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human lung cancer |
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IHC Recommend dilution: |
25-100 |
