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Background: |
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals, causing thiopurine S-methyltransferase deficiency. Related pseudogenes have been identified on chromosomes 3, 18 and X. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
TPMT |
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Immunogen: |
Fusion protein of human TPMT |
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Full name: |
thiopurine S-methyltransferase |
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Synonyms: |
TPMTD |
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SwissProt: |
P51580 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human cervical cancer |
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IHC Recommend dilution: |
40-200 |
