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ÖÐÎÄÃû³Æ£º  Íÿ¹PIM2¶à¿Ë¡¿¹Ìå


Ó¢ÎÄÃû³Æ£º  Anti-PIM2 rabbit polyclonal antibody


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¿¹       Ô­£º  PIM2


ËÞ       Ö÷£º  Rabbit


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¿Ë¡ÀàÐÍ£º  rabbit polyclonal


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Background:

This gene encodes a protooncogene that acts as a serine/threonine protein kinase. Studies determined the encoded protein functions to prevent apoptosis and to promote cell survival. Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity.

Applications:

ELISA, IHC

Name of antibody:

PIM2

Immunogen:

Fusion protein of human PIM2

Full name:

pim-2 oncogene

SwissProt:

Q9P1W9

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human thyroid cancer

IHC Recommend dilution:

50-200





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