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中文名称：小鼠抗FHIT单克隆抗体
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Background: |
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. |
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Applications: |
WB, IHC |
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Name of antibody: |
FHIT |
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Immunogen: |
Fusion protein of human FHIT |
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Full name: |
fragile histidine triad |
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Synonyms: |
FRA3B; AP3Aase |
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SwissProt: |
P49789 |
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IHC positive control: |
Human kidney tissue |
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IHC Recommend dilution: |
200-500 |
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WB Predicted band size: |
17 KD |
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WB Positive control: |
Rat brain tissue, Rat kidney tissue lysates |
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WB Recommended dilution: |
200-1000 |
