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中文名称： 兔抗UBE2K多克隆抗体
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Background: |
Protein ubiquitination requires the concerted action of the E1, E2, and E3 ubiquitin-conjugating enzymes. Ubiquitin is first activated through ATP-dependent formation of a thiol ester with ubiquitin-activating enzyme E1. The activated ubiquitin is then transferred to a thiol group of ubiquitin-carrier enzyme E2. The final step is the transfer of ubiquitin from E2 to an ε-amino group of the target protein lysine residue, which is mediated by ubiquitin-ligase enzyme E3. E2-25K (Hip2) is a member of the E2 protein family that catalyzes multiubiquitin chain synthesis via Lys48 of ubiquitin. E2-25K is reportedly involved in Alzheimer's disease, Huntington's disease and antigen processing through its interaction with amyloid-β, huntingtin, and MHC-heavy chain proteins. Lys14 of E2-25K can be modified by SUMOylation, with this modification resulting in inhibited E2 activity. |
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Applications: |
WB |
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Name of antibody: |
UBE2K |
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Immunogen: |
Fusion protein of human UBE2K |
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Full name: |
ubiquitin-conjugating enzyme E2K |
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Synonyms： |
UBE2K; DKFZp564C1216; DKFZp686J24237; E2-25K; HIP2; HYPG; LIG |
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SwissProt: |
P61086 |
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WB Predicted band size: |
22 kDa |
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WB Positive control: |
Human brain tissue |
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WB Recommended dilution: |
500-2000 |
