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Background: |
Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
EDEM1 |
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Immunogen: |
Synthetic peptide of human EDEM1 |
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Full name: |
ER degradation enhancing alpha-mannosidase like protein 1 |
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Synonyms: |
EDEM |
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SwissProt: |
Q92611 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer;Human gastric cancer |
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IHC Recommend dilution: |
10-50 |
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