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中文名称：CCT5抗原（重组蛋白）
英文名称： CCT5 Antigen (Recombinant Protein)
别 名： CCTE; HEL-S-69; PNAS-102; CCT-epsilon; TCP-1-epsilon
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 342-541 amino acids of human CCT5 |
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Full name: |
chaperonin containing TCP1 subunit 5 |
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Synonyms: |
CCTE; HEL-S-69; PNAS-102; CCT-epsilon; TCP-1-epsilon |
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Swissprot: |
P48643 |
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Gene Accession: |
BC006543 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary sensory and autonomic neuropathy with spastic paraplegia (HSNSP). Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 13. |
