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    CAPN3 Antigen (Recombinant Protein)

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    Fusion protein corresponding to a region derived from 666-821 amino acids of human CAPN3


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    Full name:

    calpain 3

    Synonyms:

    p94; CANP3; LGMD2; nCL-1; CANPL3; LGMD2A

    Swissprot:

    P20807

    Gene Accession:

    BC003521

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    Calpain, a heterodimer consisting of a large and a small subunit, is a major intracellular protease, although its function has not been well established. This gene encodes a muscle-specific member of the calpain large subunit family that specifically binds to titin. Mutations in this gene are associated with limb-girdle muscular dystrophies type 2A. Alternate promoters and alternative splicing result in multiple transcript variants encoding different isoforms and some variants are ubiquitously expressed.


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