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中文名称：ATP6V0A1 抗原（重组蛋白）
英文名称： ATP6V0A1 Antigen (Recombinant Protein)
别 名： ATPase H+ transporting V0 subunit a1; a1; Stv1; VPP1; Vph1; ATP6N1; ATP6N1A
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to a region derived from 1-200 amino acids of human ATP6V0A1 |
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Full name: |
ATPase H+ transporting V0 subunit a1 |
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Synonyms: |
a1; Stv1; VPP1; Vph1; ATP6N1; ATP6N1A |
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Swissprot: |
Q93050 |
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Gene Accession: |
BC032398 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles. Three transcript variants encoding different isoforms have been found for this gene. |
