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021-54845833/15800441009
中文名称：BMI1抗原（重组蛋白）
英文名称： BMI1 Antigen (Recombinant Protein)
别 名： PCGF4; RNF51; FLVI2/BMI1
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
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Fusion protein corresponding to N terminal 250 amino acids of human BMI1 |
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Full name: |
BMI1 polycomb ring finger oncogene |
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Synonyms: |
PCGF4; RNF51; FLVI2/BMI1 |
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Swissprot: |
P35226 |
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Gene Accession: |
BC011652 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
BMI1 polycomb ring finger oncogene, also known as BMI1, is a protein which in humans is encoded by the BMI1gene. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
