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Ó¢ÎÄÃû³Æ£º PARD6A Antigen (Recombinant Protein)

±ð      Ãû£º PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

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Fusion protein corresponding to C terminal 300 amino acids of human PARD6A

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Full name:

par-6 family cell polarity regulator alpha

Synonyms:

PAR6; PAR6C; TAX40; PAR-6A; TIP-40; PAR6alpha

Swissprot:

Q9NPB6

Gene Accession:

BC015626

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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