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中文名称：TNF 抗原（重组蛋白）
英文名称： TNF Antigen (Recombinant Protein)
别 名： tumor necrosis factor; DIF; TNFA; TNFSF2; TNF-alpha
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 57-233 amino acids of human TNF |
|
Full name: |
tumor necrosis factor |
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Synonyms: |
DIF; TNFA; TNFSF2; TNF-alpha |
|
Swissprot: |
P01375 |
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Gene Accession: |
BC028148 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. |
