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021-54845833/15800441009
中文名称：ACTN4抗原（重组蛋白）
英文名称： ACTN4 Antigen (Recombinant Protein)
别 名： FSGS; FSGS1; ACTININ-4
储 存： 冷冻（-20℃）
相关类别： 抗原
概 述：
|
Fusion protein corresponding to a region derived from 50-269 amino acids of human ACTN4 |
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Full name: |
actinin, alpha 4 |
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Synonyms: |
FSGS; FSGS1; ACTININ-4 |
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Swissprot: |
O43707 |
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Gene Accession: |
BC005033 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. |
