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英文名称： Anti-PPM1D mouse monoclonal antibody
抗 原： PPM1D
克隆类型： mouse monoclonal
技术规格
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Background: |
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development. |
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Applications: |
WB |
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Name of antibody: |
PPM1D |
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Immunogen: |
Fusion protein of human PPM1D |
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Full name: |
protein phosphatase, Mg2+/Mn2+ dependent 1D |
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Synonyms: |
WIP1; IDDGIP; PP2C-DELTA |
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SwissProt: |
O15297 |
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WB Predicted band size: |
67 KD |
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WB Positive control: |
Jurkat, HEK293, Hela cell lysates |
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WB Recommended dilution: |
500-2000 |
