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021-54845833/15800441009
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Background: |
The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
ERN2 |
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Immunogen: |
Synthetic peptide of human ERN2 |
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Full name: |
endoplasmic reticulum to nucleus signaling 2 |
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Synonyms： |
IRE1b; IRE1-BETA |
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SwissProt: |
Q76MJ5 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human liver cancer and Human gastric cancer |
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IHC Recommend dilution: |
50-200 |
