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Background: |
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. |
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Applications: |
WB, IHC |
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Name of antibody: |
SHMT2 |
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Immunogen: |
Fusion protein of human SHMT2 |
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Full name: |
serine hydroxymethyltransferase 2 |
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Synonyms: |
GLYA; SHMT; HEL-S-51e |
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SwissProt: |
P34897 |
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IHC positive control: |
Human endometrial cancer and Human breast tissue; Human colorectal cancer and Human breast cancer |
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IHC Recommend dilution: |
200-500 |
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WB Predicted band size: |
56 KD |
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WB Positive control: |
Hela, 293T, HepG2, MCF7, Jurkat, K562 and A549 cell lysates |
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WB Recommended dilution: |
500-2000 |
