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    ÖÐÎÄÃû³Æ£ºBACE1¿¹Ô­£¨ÖØ×éµ°°×£©

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    BACE1 Antigen (Recombinant Protein)

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    Fusion protein corresponding to C terminal 300 amino acids of human BACE1


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    Full name:

    beta-site APP-cleaving enzyme 1

    Synonyms:

    ASP2; BACE; HSPC104

    Swissprot:

    P56817

    Gene Accession:

    BC065492

    Purity:

    >85%, as determined by Coomassie blue stained SDS-PAGE

    Expression system:

    Escherichia coli

    Tags:

    His tag C-Terminus, GST tag N-Terminus

    Background:

    Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene.


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