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021-54845833/15800441009
技术规格
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Background: |
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
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Applications: |
WB, IHC, IF |
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Name of antibody: |
IGF1R(Phospho-Tyr1161) |
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Immunogen: |
Peptide sequence around phosphorylation site of tyrosine 1161(D-I-Y(p)-E-T)derived from Human IGF-1R. |
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Full name: |
insulin-like growth factor 1 receptor |
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Synonyms： |
IGFR; CD221; IGFIR; JTK13 |
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SwissProt: |
P08069 |
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IHC positive control: |
Human breast carcinoma tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
155 kDa |
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WB Positive control: |
293 cells lysates untreated or treated with insulin |
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WB Recommended dilution: |
500-1000 |
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IF positive control: |
MCF7 cells |
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IF Recommend dilution: |
100-200 |
