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中文名称：小鼠抗GRN单克隆抗体
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Background: |
Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. |
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Applications: |
WB, IHC |
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Name of antibody: |
GRN |
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Immunogen: |
Fusion protein of human GRN |
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Full name: |
granulin precursor |
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Synonyms: |
GEP; GP88; PEPI; PGRN; CLN11; PCDGF |
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SwissProt: |
P28799 |
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IHC positive control: |
Human pancreas tissue and Human spleen tissue; Human endometrium tissue and Human appendix tissue |
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IHC Recommend dilution: |
200-500 |
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WB Predicted band size: |
64 KD |
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WB Positive control: |
A431, 293T, MCF7 and Hela cell lysates |
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WB Recommended dilution: |
200-1000 |
