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021-54845833/15800441009
中文名称 : 小鼠抗GCLC单克隆抗体
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Background: |
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct |
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Applications: |
WB, IHC |
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Name of antibody: |
GCLC |
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Immunogen: |
Fusion protein of human GCLC |
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Full name: |
glutamate-cysteine ligase, catalytic subunit (GCLC), transcript variant 1 |
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Synonyms: |
GCL; GCS; GLCL; GLCLC |
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SwissProt: |
P48506 |
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IHC positive control: |
human pancreas tissue and carcinoma of human thyroid tissue |
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IHC Recommend dilution: |
30-150 |
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WB Predicted band size: |
73 kDa |
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WB Positive control: |
HepG2, A549, COS7, Jurkat, PC12, MCF-7 cell lysates |
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WB Recommended dilution: |
200-1000 |
