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Íÿ¹CISH¶à¿Ë¡¿¹Ìå


Ó¢ÎÄÃû³Æ£ºAnti-CISH rabbit polyclonal antibody

±ð      Ãû£ºCIS; G18; SOCS; CIS-1; BACTS2

¿¹      Ô­£ºCISH

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´¢      ´æ£ºÀä¶³£¨-20¡æ£©

ËÞ      Ö÷£ºRabbit

·´Ó¦ÖÖÊô£ºHuman, Mouse, Rat

±ê ¼Ç ÎUnconjugate

¿Ë¡ÀàÐÍ£ºrabbit polyclonal

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Background:

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

CISH

Immunogen:

Fusion protein of human CISH

Full name:

cytokine inducible SH2 containing protein

Synonyms:

CIS; G18; SOCS; CIS-1; BACTS2

SwissProt:

Q9NSE2

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human esophagus cancer and Human thyroid cancer

IHC Recommend dilution:

100-300








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