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021-54845833/15800441009
中文名称： 小鼠抗E2F1单克隆抗体
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Background: |
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. |
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Applications: |
WB, IF, IP |
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Name of antibody: |
E2F1 |
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Immunogen: |
Fusion protein of human E2F1 |
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Full name: |
E2F transcription factor 1 |
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Synonyms: |
RBP3; E2F-1; RBAP1; RBBP3 |
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SwissProt: |
Q01094 |
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WB Predicted band size: |
47 kDa |
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WB Positive control: |
C6, Raw264.7 and Hela cell lysates |
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WB Recommended dilution: |
500-2000 |
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IF positive control: |
Hela cells |
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IF Recommend dilution: |
50-100 |
