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中文名称： UBE2D1 抗原（重组蛋白）
英文名称： UBE2D1 Antigen (Recombinant Protein)
别 名： ubiquitin conjugating enzyme E2 D1; SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1
相关类别：抗原
储 存： 冷冻（-20℃）
概 述
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Full name: |
ubiquitin conjugating enzyme E2 D1 |
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Synonyms: |
SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1 |
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Swissprot: |
P51668 |
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Gene Accession: |
BC005980 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene. |
