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中文名称： TRPC4AP 抗原（重组蛋白）
英文名称： TRPC4AP Antigen (Recombinant Protein)
别 名： transient receptor potential cation channel, subfamily C, member 4 associated protein; TRUSS; TRRP4AP; PPP1R158; C20orf188
储 存： 冷冻（-20℃）
相关类别：抗原
概 述
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Full name: |
transient receptor potential cation channel, subfamily C, member 4 associated protein |
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Synonyms: |
TRUSS; TRRP4AP; PPP1R158; C20orf188 |
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Swissprot: |
Q8TEL6 |
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Gene Accession: |
BC013144 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
TRPC4AP (transient receptor potential cation channel, subfamily C, member 4 associated protein), also known as TRUSS or TRRP4AP, is a 797 amino acid protein that is expressed in a variety of tissues, with highest expression in liver, heart, testis and brain. Thought to function as a scaffolding protein, TRPC4AP interacts with TNF-R1 and may both link TNF-R1 to the IKK signalsome complex, and participate in the activation of NFκB p50, an event that occurs in response to TNF-R1 ligation. TRPC4AP exists as multiple alternatively spliced isoforms that are encoded by a gene which maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. |
