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中文名称： STAP1 抗原（重组蛋白）
英文名称： STAP1 Antigen (Recombinant Protein)
别 名： signal transducing adaptor family member 1; BRDG1; STAP-1
相关类别：抗原
储 存： 冷冻（-20℃）
概 述
技术规格
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Full name: |
signal transducing adaptor family member 1 |
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Synonyms: |
BRDG1; STAP-1 |
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Swissprot: |
Q9ULZ2 |
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Gene Accession: |
BC014958 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene contains a proline-rich region, a pleckstrin homology (PH) domain, and a region in the carboxy terminal half with similarity to the Src Homology 2 (SH2) domain. This protein is a substrate of tyrosine-protein kinase Tec, and its interaction with tyrosine-protein kinase Tec is phosphorylation-dependent. This protein is thought to participate in a positive feedback loop by upregulating the activity of tyrosine-protein kinase Tec. Variants of this gene have been associated with autosomal-dominant hypercholesterolemia (ADH), which is characterized by elevated low-density lipoprotein cholesterol levels and in increased risk of coronary vascular disease. Alternative splicing results in multiple transcript variants. |
