Name: TFEB 抗原（重组蛋白）
Brand: 通蔚生物

中文名称：TFEB 抗原（重组蛋白）

英文名称：TFEB Antigen (Recombinant Protein)

别名： transcription factor EB; TCFEB; BHLHE35; ALPHATFEB

储存： 冷冻（-20℃）

相关类别：抗原

概述

Fusion protein corresponding to a region derived from 300-476 amino acids of human TFEB

技术规格

Full name:	transcription factor EB
Synonyms:	TCFEB; BHLHE35; ALPHATFEB
Swissprot:	P19484
Gene Accession:	BC032448
Purity:	>85%, as determined by Coomassie blue stained SDS-PAGE
Expression system:	Escherichia coli
Tags:	His tag C-Terminus, GST tag N-Terminus
Background:	Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1.

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