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中文名称： TAB1 抗原（重组蛋白）
英文名称： TAB1 Antigen (Recombinant Protein)
别 名： TGF-beta activated kinase 1/MAP3K7 binding protein 1; 3'-Tab1; MAP3K7IP1
储 存： 冷冻（-20℃）
相关类别：抗原
概 述
技术规格
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Full name: |
TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
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Synonyms: |
3'-Tab1; MAP3K7IP1 |
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Swissprot: |
Q15750 |
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Gene Accession: |
BC050554 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. |
