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Fusion protein corresponding to a region derived from 484-666 amino acids of human PROS1 |
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Full name: |
protein S (alpha) |
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Synonyms: |
PSA; PROS; PS21; PS22; PS23; PS24; PS25; THPH5; THPH6 |
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Swissprot: |
P07225 |
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Gene Accession: |
BC015801 |
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Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
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Expression system: |
Escherichia coli |
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Tags: |
His tag C-Terminus, GST tag N-Terminus |
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Background: |
This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. |
