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021-54845833/15800441009
中文名称：兔抗BRCA2多克隆抗体
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Background: |
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
BRCA2 |
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Immunogen: |
Synthetic peptide of humanBRCA2 |
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Full name: |
Breast cancer type 2 susceptibility protein |
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Synonyms： |
FAD, FACD, FAD1, GLM3, BRCC2, FANCB, FANCD, PNCA2, FANCD1, BROVCA2 |
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SwissProt: |
P51587 |
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ELISA Recommended dilution: |
2000-5000 |
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IHC positive control: |
Human lung cancer |
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IHC Recommend dilution: |
25-100 |
