购物车
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021-54845833/15800441009
中文名称：兔抗Baz2a多克隆抗体
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Background: |
Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter; pRNA-binding is required for heterochromatin formation and rDNA silencing By similarity. |
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Applications: |
WB |
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Name of antibody: |
Baz2a |
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Immunogen: |
Synthesized peptide derived from internal of human BAZ2A. |
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Full name: |
bromodomain adjacent to zinc finger domain, 2A |
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Synonyms： |
TIP5; WALp3 |
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SwissProt: |
Q9UIF9 |
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WB Predicted band size: |
211 kDa |
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WB Positive control: |
Jurkat cells lysate |
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WB Recommended dilution: |
500-3000 |
