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021-54845833/15800441009
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Background: |
This gene encodes a member of the E protein (class I) family of helix-loop-helix transcription factors. E proteins activate transcription by binding to regulatory E-box sequences on target genes as heterodimers or homodimers, and are inhibited by heterodimerization with inhibitor of DNA-binding (class IV) helix-loop-helix proteins. E proteins play a critical role in lymphopoiesis, and the encoded protein is required for B and T lymphocyte development. Deletion of this gene or diminished activity of the encoded protein may play a role in lymphoid malignancies. This gene is also involved in several chromosomal translocations that are associated with lymphoid malignancies including pre-B-cell acute lymphoblastic leukemia (t(1;19), with PBX1), childhood leukemia (t(19;19), with TFPT) and acute leukemia (t(12;19), with ZNF384). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Sep 2011] |
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Applications: |
IHC |
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Name of antibody: |
TCF3(Phospho-Thr355) |
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Immunogen: |
Peptide sequence around phosphorylation site of threonine 355 (P-S-T(p)-P-V) derived from Human E2A . |
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Full name: |
transcription factor 3 |
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Synonyms： |
E2A; E47; ITF1; VDIR; TCF-3; bHLHb21 |
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SwissProt: |
P15923 |
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IHC positive control: |
Human brain tissue |
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IHC Recommend dilution: |
50-100 |
