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021-54845833/15800441009
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Background: |
Speedy A, also known as SPDYA, SPDY1, Ringo3 or SPY1, is a 313 amino acid protein that localizes to the nucleus and belongs to the speedy/ringo family. Expressed at high levels in testis and at lower levels in brain, kidney, heart, bone marrow, colon, lung, liver spleen and placenta, Speedy A functions to regulate the G1/S phase transition of the cell cycle, specifically by binding to and activating Cdc2 p34, Cdk2 and p27. Additionally, Speedy A mediates cell survival during DNA damage, suggesting that Speedy A plays a role in proper cell cycle progression throughout the life of the cell. Multiple isoforms of Speedy A exist due to alternative splicing events. The gene encoding Speedy A maps to human chromosome 2, which encodes over 1,400 genes and comprises nearly 8% of the human genome. |
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Applications: |
WB |
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Name of antibody: |
SPDYA |
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Immunogen: |
Fusion protein of human SPDYA |
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Full name: |
speedy homolog A (Xenopus laevis) |
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Synonyms： |
MGC110856; MGC57218; Ringo3; SPDY1; SPY1 |
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SwissProt: |
Q5MJ70 |
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WB Predicted band size: |
36 kDa |
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WB Positive control: |
NT2D1, PC3 and U-67 cells |
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WB Recommended dilution: |
500-2000 |
