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021-54845833/15800441009
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Background: |
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. |
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Applications: |
ELISA, IHC |
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Name of antibody: |
SNCA |
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Immunogen: |
Synthetic peptide of human SNCA |
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Full name: |
synuclein, alpha (non A4 component of amyloid precursor) |
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Synonyms： |
PD1; NACP; PARK1; PARK4 |
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SwissProt: |
P37840 |
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ELISA Recommended dilution: |
1000-2000 |
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IHC positive control: |
Human brain and Human thyroid cancer |
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IHC Recommend dilution: |
25-100 |
