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021-54845833/15800441009
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Background: |
This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
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Applications: |
WB, IF |
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Name of antibody: |
SMG7 |
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Immunogen: |
Synthesized peptide derived from internal of human SMG7. |
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Full name: |
SMG7 nonsense mediated mRNA decay factor |
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Synonyms： |
EST1C; SGA56M; C1orf16 |
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SwissProt: |
Q92540 |
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WB Predicted band size: |
127 kDa |
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WB Positive control: |
Hela cells, Jurkat cells, 293 cells and Huvec cells lysates |
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WB Recommended dilution: |
500-3000 |
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IF positive control: |
HepG2 cells |
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IF Recommend dilution: |
100-500 |
