购物车
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021-54845833/15800441009
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Background: |
This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP. Activating mutations in this gene are a common cause of congenital hyperinsulinism. Alternative splicing of this gene results in multiple transcript variants. The related glutamate dehydrogenase 2 gene on the human X-chromosome originated from this gene via retrotransposition and encodes a soluble form of glutamate dehydrogenase. Related pseudogenes have been identified on chromosomes 10, 18 and X. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
GLUD1 |
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Immunogen: |
Synthetic peptide of human GLUD1 |
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Full name: |
glutamate dehydrogenase 1 |
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Synonyms: |
GDH; GDH1; GLUD |
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SwissProt: |
P00367 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human tonsil |
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IHC Recommend dilution: |
20-100 |
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WB Predicted band size: |
61 kDa |
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WB Positive control: |
Mouse liver tissue and Rat liver tissue lysates |
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WB Recommended dilution: |
500-2000 |
