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021-54845833/15800441009
中文名称： 兔抗UNC45B多克隆抗体
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Background: |
This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. |
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Applications: |
ELISA, WB, IHC |
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Name of antibody: |
UNC45B |
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Immunogen: |
Fusion protein of human UNC45B |
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Full name: |
unc-45 myosin chaperone B |
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Synonyms: |
CMYA4; UNC45; CTRCT43; SMUNC45; UNC-45B |
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SwissProt: |
Q8IWX7 |
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ELISA Recommended dilution: |
5000-10000 |
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IHC positive control: |
Human liver cancer |
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IHC Recommend dilution: |
50-300 |
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WB Predicted band size: |
104/95 kDa |
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WB Positive control: |
Human heart tissue lysate |
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WB Recommended dilution: |
500-2000 |
